1) nearly every single justification one can imagine might make one want to close a comics and manga and anime store gets a mention in kind of a It's a Mad, Mad, Mad, Mad World of retailer complaints, including one or two that can't be true (Marvel's publishing arm is doing fine, for instance).
2) it makes note of a downturn (at least a local one) in the gaming market I generally know little to nothing about that I'm sure has had a great effect on comics shops that sell that material. It also mentions how much in terms of physical resources can be spent giving gamers space to play their games, and how that could be utilized in a different way, which is something I never thought about.
3) after bagging on the chaotic marketplace they end the note with a pitch for someone to buy the store. This is doubly funny in that one can imagine some fans would run the numbers in their head even if they were told the building was radioactive.